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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN3
All Species:
26.06
Human Site:
S27
Identified Species:
71.67
UniProt:
P26045
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26045
NP_001138840.1
913
103990
S27
L
P
K
E
K
T
R
S
E
V
I
C
S
I
H
Chimpanzee
Pan troglodytes
XP_520179
913
103998
S27
L
P
K
E
K
T
R
S
E
V
I
C
S
I
H
Rhesus Macaque
Macaca mulatta
XP_001107076
913
104134
S27
L
P
K
E
K
T
R
S
E
V
I
C
S
I
Y
Dog
Lupus familis
XP_853516
913
104010
S27
L
P
K
E
K
T
R
S
E
I
V
C
S
I
R
Cat
Felis silvestris
Mouse
Mus musculus
A2ALK8
913
103878
S27
L
P
K
E
K
T
R
S
E
V
I
C
S
I
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506800
952
108609
S66
L
P
K
E
K
T
R
S
E
I
V
C
R
I
H
Chicken
Gallus gallus
XP_419047
1136
128587
S247
L
P
K
E
K
T
R
S
E
I
T
C
N
V
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
O57457
619
70690
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
C31
P
P
P
N
Q
I
R
C
T
V
T
F
L
D
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98
94.1
N.A.
92
N.A.
N.A.
79.5
63.1
N.A.
22.7
N.A.
N.A.
N.A.
36.5
N.A.
Protein Similarity:
100
99.6
98.9
97.1
N.A.
96.3
N.A.
N.A.
86.8
71.3
N.A.
38.1
N.A.
N.A.
N.A.
53.7
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
93.3
N.A.
N.A.
80
73.3
N.A.
0
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
93.3
93.3
N.A.
0
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
12
0
0
0
78
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% D
% Glu:
0
0
0
78
0
0
0
0
78
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
45
% H
% Ile:
0
0
0
0
0
12
0
0
0
34
45
0
0
67
0
% I
% Lys:
0
0
78
0
78
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
78
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
12
0
0
0
0
0
0
0
0
12
0
0
% N
% Pro:
12
89
12
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
89
0
0
0
0
0
12
0
23
% R
% Ser:
0
0
0
0
0
0
0
78
0
0
0
0
56
0
12
% S
% Thr:
0
0
0
0
0
78
0
0
12
0
23
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
56
23
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _